Description
PROTEOLYTIC ENZYMES ARE ADMINISTERED TO HASTEN THE HEALING OF DAMAGED TISSUE AND THUS PROMOTE A COMPLICATION FREE RECOVERY. TRYPSIN AND CHYMOTRYPSIN ARE GIVEN AS ENTERIC COATED TABLETS TO PREVENT THE DESTRUCTION IN ACIDIC MEDIUM OF STOMACH AND PROMOTE ABSORPTION FROM SMALL INTESTINE.
PHARMACOLOGY
A.)PHARMACODYNAMICS:
On being absorbed, the enzymes are taken up by the circulating enzyme inhibitors i.e. alpha antitrypsin and alpha 2 macroglobuline, level ol which rise steeply following injury and tissue destruction. This rise in inhibitor levels is responsible for the period of operative fibrinolytic shut down and maintenance of inflammatory edema which delay healing. These also facilitate the action of plasmin which is necessary to open up the blocked microcirculation, resolve edema and initiate healing.
INDICATIONS: –
- Resolution of active inflammatory oedema associated with accidental and surgical trauma pelvic inflammatory disorder, sciatica.
- To reduce the viscosity of mucus and sputum in bronchitis, rhinitis and sinusitis, dental extraction.
- Enhancing antibiotic concentration at the site of infection.
