Description
OFLOXACIN IS A SYNTHETIC ANTIBIOTIC OF THE FLUOROQUINOLONE DRUG CLASS CONSIDERED TO BE A SECOND-GENERATION FLUOROQUINOLONE.
PHARMACOLOGY
PHARMACODYNAMICS:
Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
PHARMACOKINETICS
- Absorption: – Bioavailability of ofloxacin in the tablet formulation is approximately 98%.
- Protein binding: – 32%
- Metabolism: – Hepatic
- Route of elimination: – Elimination is mainly by renal excretion. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Four to eight percent of an ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.
- Half life: – 9 hours
- Bioavailability: – Ofloxacin in the tablet form is approximately 98% following oral administration reaching maximum serum concentrations within one to two hours.
INDICATIONS:
For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhea.
