Description
OFLOXACIN:
Ofloxacin is a ʻquinoloneʼ antibiotic used for treating certain kinds of bacterial infections (ear infections, urinary tract infections) and also useful in pelvic inflammatory disease (PID). It belongs to the fluoroquinolone class of antibiotics. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA).
ORNIDAZOLE:
Ornidazole is a nitro-imidazole which is an antibacterial and antiprotozoal drug used to treat anaerobic enteric protozoa. It is a drug that cures some protozoan infections like (Giardiasis, Trichomoniasis). This antibacterial agent is effective against a wide variety of gram-negative and gram-positive aerobic bacteria.
PHARMACOLOGY
PHARMACODYNAMICS:
This combination has vitro activity against a broad spectrum of gram-positive and gram negative aerobic and anaerobic bacteria.
Ofloxacin is thought to exert a bactericidal effect on susceptible microorganisms by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription, and repair of bacterial DNA. Ofloxacin has been shown to be active against most strains of the following microorganisms both in vitro and in specific clinical infections.
PHARMACOKINETICS:
A modified simple, selective, rapid, precise reversed phase high performance liquid chromatography method has been developed and validated for the simultaneous estimation of ofloxacin and ornidazole. This combination is used as various G.I tract infections worldwide. The retention time of ofloxacin and ornidazole was 2.84 min and 4.39 min respectively.
INDICATIONS:
OFLOXACIN:
On therapy for the treatment of patients ofloxacin suspension help to cure Mild to moderate infection due to susceptible strains of designated microorganisms. It is used to treat certain prostate infections and sexually transmitted infections.
ORNIDAZOLE:
Trichomoniasis of uro-genital tract and bacterial vaginosis. Ornidazole suspension is used in the treatment and prophylaxis of susceptible anaerobic infections in dental and gastrointestinal surgery.
