Description
MOXIFLOXACIN
Treating eye infections caused by certain bacteria. Moxifloxacin drops are a fluoroquinolone. It works by killing sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.
MECHANISM OF ACTION
Moxifloxacin is a member of the fluoroquinolone class of anti-infective drugs.
PHARMACOKINETICS
Moxifloxacin steady-state plasma pharmacokinetics were evaluated in healthy adult male and female subjects who were administered multiple bilateral,topical ocular doses of MOXEZA™ solution two times daily for four days with a final dose on day 5. The average steady-state AUC0-12 was 8.17 ± 5.31 ng•h/mL. Moxifloxacin Cmax following twice-daily bilateral ophthalmic administration of moxifloxacin AF 0.5% for 5 days is approximately 0.02% of that achieved with the oral formulation of moxifloxacin hydrochloride (Cmax following oral dosing of 400 mg AVELOX*, 4.5 ± 0.5 mcg/mL).
